General Information

  • ID:  hor000457
  • Uniprot ID:  E9G0B6
  • Protein name:  Allatostatin A4
  • Gene name:  NA
  • Organism:  Daphnia pulex (Water flea)
  • Family:  Allatostatin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Daphnia (genus), Daphniidae (family), Anomopoda (infraorder), Cladocera (suborder), Diplostraca (order), Phyllopoda (subclass), Branchiopoda (class), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  NA

Sequence Information

  • Sequence:  NPTKYNFGL
  • Length:  9(130-138)
  • Propeptide:  MLFLSTALFLLVALLQSSQCTDVNNDSSVIEAVGAGGGDSQAKAESLASAEDKLSALTADGMATRARYFKSFGGNPTGDPNLNIYSFGLGKRTSRSYSINPYSFGLGKRGGNAKSYPQQIPYSFGLGKRNPTKYNFGLGKRPDRFGFGLGKRNLKDDDLDQWLNDEEYSQFDDTEEEIEGREDDSQEIMDVNKRSQMAAGQQQQQQQQAFFPSHLQSAFYGGPFMSNLARANTHALGKSRTFNQQAATHDLPNLG
  • Signal peptide:  MLFLSTALFLLVALLQSSQC
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-E9G0B6-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor000457_AF2.pdbhor000457_ESM.pdb

Physical Information

Mass: 119605 Formula: C49H72N12O14
Absent amino acids: ACDEHIMQRSVW Common amino acids: N
pI: 9.3 Basic residues: 1
Polar residues: 5 Hydrophobic residues: 2
Hydrophobicity: -92.22 Boman Index: -1270
Half-Life: 1.4 hour Half-Life Yeast: 3 min
Half-Life E.Coli: >10 hour Aliphatic Index 43.33
Instability Index: -1101.11 Extinction Coefficient cystines: 1490
Absorbance 280nm: 186.25

Literature

  • PubMed ID:  21830762
  • Title:  Genomics, Transcriptomics, and Peptidomics of Daphnia Pulex Neuropeptides and Protein Hormones